GLUTATHIONE ADDITION TO PARENTERAL NUTRITION PREVENTS PULMONARY OXIDATIVE STRESS AND HYPO-ALVEOLARIZATION IN NEWBORN GUINEA PIG
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چکیده
منابع مشابه
Ascorbylperoxide contaminating parenteral nutrition perturbs the lipid metabolism in newborn guinea pig.
The light exposure of parenteral nutritive solutions generates peroxides such as H(2)O(2) and ascorbylperoxide [2,3-diketo-4-hydoxyperoxyl-5,6-dihydroxyhexanoic acid]. This absence of photoprotection is associated with higher plasma triacylglycerol (TG) concentration in premature infants and oxidative stress and H(2)O(2)-independent hepatic steatosis in animals. We hypothesized that ascorbylper...
متن کاملAscorbylperoxide from parenteral nutrition induces an increase of redox potential of glutathione and loss of alveoli in newborn guinea pig lungs
BACKGROUND Bronchopulmonary dysplasia is one of the main complications associated with extreme prematurity. Oxidative stress is suspected to be a trigger event of this lung disease, which is characterized by impaired alveolar development. Peroxides, mainly ascorbylperoxide and H2O2, are known contaminant of parenteral nutrition. We hypothesize that these oxidant molecules induce bronchopulmonar...
متن کاملJPET #166223 1 Title Page Ascorbylperoxide contaminating parenteral nutrition perturbs the lipid metabolism in newborn guinea pig
The light exposure of parenteral nutritive solutions generates peroxides such as H2O2 and ascorbylperoxide. This absence of photo-protection is associated with higher plasma triacylglycerol concentration (TG) in premature infants and, in animals, with oxidative stress and a H2O2 independent hepatic steatosis. We hypothesized that ascorbylperoxide is the active agent leading to high TG. The aim ...
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Background: The immaturity of glutathione metabolism is believed to explain the oxidative stress observed in premature neonates on total parenteral nutrition [TPN]. Animal studies report that peroxides contaminating TPN induce the low glutathione levels as a consequence of the inhibition of the generation of substrates for its synthesis. We hypothesize that older children receiving long-term TP...
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Thyroid hormones from the thyroid gland are necessary for the normal development of body organs. It was demonstrated that NO participates in the regulation of thyroid function. NO brings about oxidation reactions which will produce free radicals, and can start chain reactions that damage cells. This leads to the production of ROS. These oxidants can damage cells by starting chemical chain react...
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ژورنال
عنوان ژورنال: Paediatrics & Child Health
سال: 2018
ISSN: 1205-7088,1918-1485
DOI: 10.1093/pch/pxy054.053